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Image #   99068A
Name:   Muscle myoblast extracellular matrix
Copyright:   Copyright 2009 Dennis Kunkel Microscopy, Inc.
Description:   Caption: Muscle myoblast (primitive embryonic muscle cell) secreting extracellular matrix (ECM). A myoblast is a type of stem cell that occurs in muscles. Skeletal muscle fibers are made when myoblasts fuse together. As a result muscle fibers have multiple nuclei. The extracellular matrix (ECM) is a complex structural tissue component surrounding and supporting cells in mammalian tissues. The ECM is often referred to as the connective tissue. The ECM is composed of 3 major classes of biomolecules: 1) Structural proteins - collagen and elastin, 2) Specialized proteins - such as: fibrillin, fibronectin, and laminin and 3) Proteoglycans - complex proteins and long chains of repeating disaccharide units called glycosaminoglycans (GAGs, such as: hyaluronic acid, chondroitin sulfate, heparin, heparan sulfate). Collagens are the most abundant proteins found in the animal kingdom. It is the major protein comprising the ECM. There are at least 12 types of collagen. Collagens are predominantly formed by fibroblasts but epithelial cells also synthesize these proteins. Fibronectins attach cells to a variety of extracellular matrices. Fibronectin attaches cells to all matrices except type IV that involves laminin as the adhesive molecule. Laminin anchors cell surfaces to the basal lamina. All basal laminae contain a common set of proteins and GAGs. These are type IV collagen, heparan sulfate proteoglycans, entactin and laminin. The basal lamina is often referred to as the type IV matrix. Many cells bind to components of the extracellular matrix. The cell to ECM adhesion is regulated by specific cell surface cellular adhesion molecules (CAM) known as integrins. The integrins transmit mechanical stimuli from the ECM to the cytoskeleton.
Magnification*: x5,000
Type: SEM
    *(Magnifications are based on a 35mm slide image of 24mm in the narrow dimension.)
Keywords:   99068A medical myoblast cell muscle SEM animal cell animal cells muscle cell muscle cells myoblast muscle cell myoblast muscle cells ECM extracellular matrix muscle somite muscle somites muscle stem cell muscle stem cells myoblast cell myoblast cells primitive muscle cell primitive muscle cells somite somites somitic muscle somitic muscle cell somitic muscle cells embryonic muscle embryonic muscle cell embryonic muscle cells embryonic muscle somite embryonic muscle somites C2 C2 muscle C2 muscle cell C2 muscle cells C2 muscle myoblast C2 muscle myoblasts embryonic skeletal muscle cell embryonic skeletal muscle cells embryonic skeletal muscle myoblast embryonic skeletal muscle myoblasts embryonic skeletal muscle somite embryonic skeletal muscle somites skeletal muscle skeletal muscle cell skeletal muscle cells skeletal muscle myoblast skeletal muscle myoblasts skeletal muscle somite skeletal muscle somites C2C12 human skeletal muscle human skeletal muscle cell human skeletal muscle cells human skeletal muscle myoblast human skeletal muscle myoblasts human skeletal muscle somite human skeletal muscle somites 04.01.09 muscle myoblast muscle myoblast stem cell muscle myoblast stem cells myoblast stem cell myoblast stem cells human muscle cell human muscle cells human muscle myoblast human muscle myoblasts human muscle somite human muscle somites stem cell stem cells

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